|Immunohistochemistry (Frozen) (IHC (F))||1:1000|
|Western Blot (WB)||1:1000|
|Tested Species reactivity||Human, Mouse, Non-human primate|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide corresponding to the c-terminus region of human dopamine transporter conjugated to KLH.|
|Storage buffer||0.01M HEPES, pH 7.5, with 0.15M NaCl, 0.01% BSA, 50% glycerol|
|Contains||0.09% sodium azide|
|Storage conditions||4°C or -20°C if preferred|
PA1-84886 detects a band at ~88 kDa in human caudate cell lysates.
Dopamine transporter (DAT), also known as solute carrier family 6, is principally expressed in the presynaptic membrane of dopaminergic nerve terminals where it mediates the rapid removal of dopamine from the synaptic cleft after neuronal stimulation. As such, DAT plays an important role in regulating the availabity of dopamine in the synaptic cleft and thus in modulating the physiological functions of dopamine. The re-uptake of dopamine by the DAT is inhibited by psychostimulants such as cocaine and amphetamine.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: DA transporter; DAT; DAT1; dopamine transporter 1; Sodium-dependent dopamine transporter; solute carrier family 6 (neurotransmitter transporter), member 3; solute carrier family 6 (neurotransmitter transporter, dopamine), member 3; Solute carrier family 6 member 3
Gene Aliases: DAT; DAT1; PKDYS; SLC6A3
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