|Immunohistochemistry (Paraffin) (IHC (P))||1:100-1:1000|
|Western Blot (WB)||1:500-1:3000|
|Tested Species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant fragment corresponding to a region within amino acids 1 and 253 of Human Dynactin 2|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS, pH 7, with 1% BSA, 20% glycerol|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
PA5-30389 targets Dynactin 2 in IF, IHC (P), and WB applications and shows reactivity with Human samples.
The PA5-30389 immunogen is recombinant fragment corresponding to a region within amino acids 1 and 253 of Human Dynactin 2.
This gene encodes a 50-kD subunit of dynactin, a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit is present in 4-5 copies per dynactin molecule. It contains three short alpha-helical coiled-coil domains that may mediate association with self or other dynactin subunits. It may interact directly with the largest subunit (p150) of dynactin and may affix p150 in place.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 50 kD dynein-associated polypeptide; 50 kDa dynein-associated polypeptide; DCTN-50; DCTN50; dynactin 2 (p50); dynactin complex 50 kD subunit; Dynactin complex 50 kDa subunit; Dynactin subunit 2; DYNAMITIN; epididymis secretory protein Li 77; p50 dynamitin; RBP50
Gene Aliases: DCTN2; DCTN50; DYNAMITIN; HEL-S-77; RBP50
UniProt ID: (Human) Q13561
Entrez Gene ID: (Human) 10540
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