|Immunohistochemistry (Paraffin) (IHC (P))||2-4 µg/ml|
|Western Blot (WB)||0.5-2 µg/ml|
|Tested Species reactivity||Human, Mouse|
|Host / Isotype||Goat / IgG|
|Immunogen||Synthetic peptide sequence (QEQLHQLHSRLIS) corresponding to the C-terminus amino acids of DCTN1|
|Purification||Antigen affinity chromatography|
|Storage buffer||TBS, pH 7.3, with 0.5% BSA|
|Contains||0.02% sodium azide|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
This antibody is predicted to react with rat based on sequence homology.
This gene encodes the largest subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. Dynactin is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit interacts with dynein intermediate chain by its domains directly binding to dynein and binds to microtubules via a highly conserved glycine-rich cytoskeleton-associated protein domain in its N-terminus. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. Mutations in this gene cause distal hereditary motor neuronopathy type VIIB which is also known as distal spinal and bulbar muscular atrophy .
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 150 kDa dynein-associated polypeptide; DAP-150; DCTN1; DP-150; dynactin 1; dynactin 1 (p150, Glued (Drosophila) homolog); dynactin 1 (p150, glued homolog, Drosophila); dynactin 1, retrograde axonal transport; Dynactin subunit 1; HMN7B; OTTHUMP00000202491; P135; p150, Glued (Drosophila) homolog; p150, Glued homolog; p150-glued
Gene Aliases: AL022633; DAP-150; DCTN1; DP-150; Glued; P135; p150; p150<glued>
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