|Immunohistochemistry (Paraffin) (IHC (P))||1:100-1:1000|
|Western Blot (WB)||1:500-1:3000|
|Tested Species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide corresponding to a region within amino acids 714 and 813 of Human Dynamin 2|
|Purification||Antigen affinity chromatography|
|Storage buffer||0.1M tris glycine, pH 7, with 10% glycerol|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
PA5-29017 targets Dynamin 2 in Immunohistochemistry (Paraffin), immunocytochemistry and western blot applications and shows reactivity with Human samples.
The PA5-29017 immunogen is synthetic peptide corresponding to a region within amino acids 714 and 813 of Human Dynamin 2.
Dynamins represent one of the subfamilies of GTP-binding proteins. These proteins share considerable sequence similarity over the N-terminal portion of the molecule, which contains the GTPase domain. Dynamins are associated with microtubules. They have been implicated in cell processes such as endocytosis and cell motility, and in alterations of the membrane that accompany certain activities such as bone resorption by osteoclasts. Dynamins bind many proteins that bind actin and other cytoskeletal proteins. Dynamins can also self-assemble, a process that stimulates GTPase activity. Four alternatively spliced transcripts encoding different proteins have been described. Additional alternatively spliced transcripts may exist, but their full-length nature has not been determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: CMT2M; CMTDI1; CMTDIB; DI-CMTB; DYN2; dynamin II; Dynamin-2; DYNII
Gene Aliases: CMT2M; CMTDI1; CMTDIB; DI-CMTB; DNM2; DYN2; DYNII; LCCS5
UniProt ID: (Human) P50570
Entrez Gene ID: (Human) 1785
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