|Western Blot (WB)||1 ug/ml|
|Tested Species reactivity||Human|
|Host / Isotype||Goat / IgG|
|Immunogen||Synthetic peptide sequence (GKCRQLSRLCRNHCR) corresponding to the C-terminus amino acids of FXYD5|
|Purification||Antigen affinity chromatography|
|Storage buffer||TBS, pH 7.3, with 0.5% BSA|
|Contains||0.02% sodium azide|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5 has been termed RIC have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members , with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. This gene product, FXYD5, is a glycoprotein that functions in the up-regulation of chemokine production, and it is involved in the reduction of cell adhesion via its ability to down-regulate E-cadherin. It also promotes metastasis, and has been linked to a variety of cancers. Alternative splicing results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: DYSAD; Dysadherin; FXYD domain containing ion transport regulator 5; FXYD domain-containing ion transport regulator 5; FXYD5; HSPC113; IWU-1; IWU1; KCT1; keratinocytes associated transmembrane protein 1; OIT2; PRO6241; RIC
Gene Aliases: DYSAD; FXYD5; HSPC113; IWU1; KCT1; OIT2; PRO6241; RIC; UNQ2561/PRO6241
UniProt ID: (Human) Q96DB9
Entrez Gene ID: (Human) 53827
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