|Western Blot (WB)||Assay dependent|
|Tested Species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant protein encoding amino acids residues 1-851 of human E6-AP expressed in E. coli.|
|Storage buffer||whole serum|
|Storage conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
PA1-23212 detects E6AP in Human samples. Customer testing reported no specific cross reactivity with Drosophila melanogaster E6AP.
PA1-23212 has been successfully used in Western Blot procedures.
PA1-23212 immunogen corresponds to Recombinant protein encoding amino acids residues 1-851 of human E6-AP expressed in E. coli..
The E6-associated protein (E6-AP/UBE3A), a 100a protein, was originally identified as an ubiquitin-protein ligase (E3), in the presence of the E6 protein from human papillomavirus types 16 and 18. E6-AP has also been shown to function as a coactivator of steroid receptor-dependent transcriptional activity. Recent data indicate that the ubiquitin-protein ligase function of E6-AP is dispensable for its ability to coactivate nuclear hormone receptors, showing that E6-AP possesses two separable independent functions, as both a coactivator and a ubiquitin-protein ligase.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: ANCR; AS; CTCL tumor antigen se37-2; E6-AP; E6AP ubiquitin-protein ligase; EPVE6AP; FLJ26981; HECT-type ubiquitin transferase E3A; HPVE6A; human papilloma virus E6-associated protein; Human papillomavirus E6-associated protein; Oncogenic protein-associated protein E6-AP; Renal carcinoma antigen NY-REN-54; Ubiquitin-protein ligase E3A
Gene Aliases: ANCR; AS; E6-AP; E6AP; EPVE6AP; HPVE6A; UBE3A
UniProt ID: (Human) Q05086
Entrez Gene ID: (Human) 7337
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