|Immunohistochemistry (Paraffin) (IHC (P))||4 µg/ml|
|Tested Species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic 17 amino acid peptide from near N-terminus of human NR2F6.|
|Purification||Antigen affinity chromatography|
|Contains||< 0.1% sodium azide|
|Storage conditions||Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C|
Percent identity with other species by BLAST analysis: Human, Monkey (100%) Mouse (94%) Dog (88%) Opossum (82%).
NR2F6, also known as Nuclear receptor subfamily 2 group F member 6, is a nuclear protein belonging to the nuclear hormone receptor family and NR2 subfamily with a nuclear receptor DNA-binding domain. NR2F6 is a nuclear receptor involved in action regulation of the transcription of the GNRH1 gene. It binds to the TGACCT repeat motif enhancing the renin gene and thus acting as a negative modulator of renin gene transcription. NR2F6 is required early in the development of the locus ceruleus (LC), thus in some way contributing to the regulation of the forebrain clock, at least in part, through targeted release of noradrenalin into the cortical area.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: EAR-2; EAR2; Erba related 2; ERBA-related gene-2; ERBAL2; NR2F6; Nuclear receptor subfamily 2 group F member 6; nuclear receptor subfamily 2, group F, member 6; nuclear receptor V-erbA-related; v-erb-a avian erythroblastic leukemia viral oncogene homolog-like 2; V-erbA-related protein 2
Gene Aliases: EAR-2; EAR2; ERBAL2; NR2F6
UniProt ID: (Human) P10588
Entrez Gene ID: (Human) 2063
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