|Western Blot (WB)||1:500-1:3000|
|Tested Species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant fragment corresponding to a region within amino acids 274 and 633 of Human ECEL1|
|Purification||Antigen affinity chromatography|
|Storage buffer||0.1M tris glycine, pH 7, with 10% glycerol|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
PA5-27951 targets ECEL1 in WB applications and shows reactivity with Human samples.
The PA5-27951 immunogen is recombinant fragment corresponding to a region within amino acids 274 and 633 of Human ECEL1.
This gene encodes a member of the M13 family of endopeptidases. In general, M13 family members are zinc-containing type II integral-membrane proteins that are important regulators of neuropeptide and peptide hormone activity. This gene is expressed specifically in the central nervous system and its protein localizes predominately to the endoplasmic reticulum or, in trace amounts, to the cell surface. Disruption of this gene in mouse embryonic stem cells results in neonatal lethality due to respiratory failure shortly after birth. Based on the specific expression of this gene and the phenotype of the gene deficiency in mouse embryos, it is suggested that this protein plays a critical role in neural regulation of the respiratory system. This gene has multiple pseudogenes.
Protein Aliases: damage induced neuronal endopeptidase; DINE; ECEX; endothelin converting enzyme-like 1; Endothelin-converting enzyme-like 1; X converting enzyme; XCE; Xce protein
Gene Aliases: DA5D; DINE; ECEL1; ECEX; UNQ2431/PRO4991; XCE
UniProt ID: (Human) O95672
Entrez Gene ID: (Human) 9427