|Immunohistochemistry (Paraffin) (IHC (P))||10 µg/ml|
|Western Blot (WB)||0.25-0.50 µg/ml|
|Tested Species reactivity||Bovine, Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide (93 PGGELSWEGNGPHHDRC 109) of EPM2A/Laforin protein.|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS with 0.05% BSA|
|Contains||0.05% sodium azide|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
EPM2A/Laforin is a novel dual-specificity phosphatase which associates with polyribosomes and belongs to the protein-tyrosine phosphatase family. Two isoforms of Laforin are reported which have alternate C termini and a common segment that consists of a carbohydrate-binding module and a dual-specificity protein phosphatase domain. Laforin plays an important role in the regulation of glycogen metabolism, prevents the formation of polyglucasans, and hydrolyze phosphotyrosine and phosphoserine/threonine substrates. Malin, a ubiquitin ligase, helps in regulation of Laforin protein concentration. Laforin not only interacts with itself but also with PPP1R5, HIRIP5 and EPM2AIP1. Mutations in the gene encoding EPM2A have been associated with myoclonic epilepsy type 2 (EPM2), also known as Lafora disease, an autosomal recessive and severe form of adolescent-onset progressive epilepsy. Multiple transcript variants of Laforin are expressed in most of the tissues, including brain.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: epilepsy; epilepsy, progressive myoclonus type 2, Lafora disease (laforin); EPM2; EPM2A; Glucan phosphatase; Lafora disease (laforin); Lafora PTPase; Laforin; LAFPTPase; MELF; progressive myoclonus type 2; RP1-28C20.2
Gene Aliases: BOS_9902; EPM2; EPM2A; laforin; MELF
UniProt ID: (Human) O95278
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