|Immunohistochemistry (Frozen) (IHC (F))||Assay Dependent|
|Immunoradiometric Assay (IRMA)||Assay Dependent|
|Tested Species reactivity||Human|
|Host / Isotype||Rat / IgG2b|
|Immunogen||Synthetic peptide corresponding to the c-terminal region of human endothelin (C,H,L,D,I,I,W), conjugated to BSA.|
|Contains||0.09% sodium azide|
|Storage conditions||4°C or -20°C if preferred|
For IHC applications, frozen sections processed with dry acetone are recommended. Paraformaldehyde is not recommended as it destroys the epitope.
The protein encoded by this gene is proteolytically processed to release a secreted peptide termed endothelin 1. This peptide is a potent vasoconstrictor and is produced by vascular endothelial cells. Endothelin 1 also can affect the central nervous system. Two transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Endothelin-1; ET1; HDLCQ7; PPET1; Preproendothelin-1
Gene Aliases: ARCND3; EDN1; ET1; HDLCQ7; PPET1; QME
UniProt ID: (Human) P05305
Entrez Gene ID: (Human) 1906
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