|Western Blot (WB)||1:1000|
|Tested Species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||KLH conjugated synthetic peptide between 29-59 amino acids from the N-terminal region of human EphB3|
|Purification||Ammonium sulfate precipitation, Size-exclusion - Dialysis|
|Contains||0.09% sodium azide|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
This antibody is predicted to react with mouse based on sequence homology.
Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. EphB3, a member of the Tyr family of protein kinases, is a receptor for members of the ephrin-B family; it binds to both ephrin-B1 and -B2. Expression of this Type I membrane protein is ubiquitous. The protein contains putative domains for 2 fibronectin type III and 1 sterile alpha motif (SAM).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: EK2; Embryonic kinase 2; EPH-like kinase 2; EPH-like tyrosine kinase 2; Ephrin type-B receptor 3; human embryo kinase 2; Tyrosine-protein kinase receptor HEK-2; Tyrosine-protein kinase TYRO6
Gene Aliases: EK2; EPHB3; ETK2; HEK2; TYRO6
UniProt ID: (Human) P54753
Entrez Gene ID: (Human) 2049
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