|ChIP assay (ChIP)||Assay-dependent|
|Immunohistochemistry (IHC)||Assay dependent|
|Western Blot (WB)||1-5 µg/ml|
|Tested Species reactivity||Human|
|Host / Isotype||Mouse / IgG2b|
|Immunogen||Amino acids 1-153 of human ER-ß expressed in E. coli.|
|Storage buffer||PBS, pH 7.4|
|Storage conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
MA1-23221 detects Estrogen Receptor Beta in Human samples.
MA1-23221 has been successfully used in Immunohistochemistry and Western Blot procedures.
MA1-23221 immunogen corresponds to Amino acids 1-153 of human ER-ß expressed in E. coli..
The human ER-beta is a newly discovered estrogen receptor initially cloned and characterized from testis. The size and structure of ER-beta is very similar to ER-alpha with the ligand and DNA binding domains being highly conserved, while the amino terminus which serves as their transactivation domain has diverged significantly. Similar in function to ER-alpha ER-beta binds to estrogen with a high affinity and regulates estrogen specific gene activation through direct interaction with estrogen response elements (ERE's).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: ER Beta; ER-beta; ESR-Beta; ESR2; estrogen receptor 2 (ER beta); Estrogen receptor beta; estrogen receptor beta 4; Nuclear receptor subfamily 3 group A member 2
Gene Aliases: ER-BETA; Erb; ESR-BETA; ESR2; ESRB; ESTRB; NR3A2
UniProt ID: (Human) Q92731
Entrez Gene ID: (Human) 2100
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