|ELISA (ELISA)||Assay Dependent|
|Western Blot (WB)||Assay Dependent|
|Tested Species reactivity||Human|
|Host / Isotype||Mouse / IgG|
|Immunogen||Purified, native human Factor VIII A2 domain.|
|Contains||0.01% sodium azide|
|Storage conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
MA1-27389 detects Factor VIII A2 domain from human samples.
MA1-27389 has been successfully used in Western blot procedures. This antibody binds both human factor VIII and human factor VIIIa in solid-phase ELISA. It binds human factor VIII A2 domain in immunoblotting techniques.
The MA1-27389 immunogen is purified, native human Factor VIII A2 domain.
Store at 4°C short term. For extended storage aliquot and store at -20°C or below. Avoid freeze/thaw cycles.
Haemophilia A is an X-linked, recessive, bleeding disorder caused by a deficiency in the activity of coagulation factor VIII. Affected individuals develop a variable phenotype of haemorrhage into joints and muscles, easy bruising, and prolonged bleeding from wounds. The disorder is caused by heterogeneous mutations in the factor VIII gene. Up to 30% of haemophilia A patients given therapeutic fVIII can make inhibitory antibodies, the majority of which are reactive with its C2 and A2 domains.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: AHF; Antihemophilic factor; Coagulation factor VIII; coagulation factor VIII A1 domain; coagulation factor VIII C2 domain; coagulation factor VIII, procoagulant component; coagulation factor VIIIc; DXS1253E; F8B; F8C; factor VIII F8B; FVIII; HEMA; Procoagulant component; RP11-115M6.7
Gene Aliases: AHF; DXS1253E; F8; F8B; F8C; FVIII; HEMA
UniProt ID: (Human) P00451
Entrez Gene ID: (Human) 2157
Molecular Function: apolipoprotein cell adhesion molecule enzyme modulator extracellular matrix protein hydrolase membrane-bound signaling molecule metalloprotease oxidase oxidoreductase protease receptor serine protease signaling molecule transfer/carrier protein transporter
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