|Inhibition Assays (IA)||5-10 µg/mL|
|Tested Species reactivity||Human|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Heavy chains of human factors Xa and X.|
|Purification||Ion-exchange chromatography, Ammonium sulfate precipitation|
|Storage buffer||50% water with 50% glycerol|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
MA1-43013 detects Factor X in human samples.
MA1-43013 has successfully been used in IA applications.
MA1-43013 was derived from the heavy chains of human factors Xa and X.
F10 undergoes multiple processing steps before its preproprotein is converted to a mature two-chain form by the excision of the tripeptide RKR. Two chains of the factor are held together by 1 or more disulfide bonds; the light chain contains 2 EGF-like domains, while the heavy chain contains the catalytic domain which is structurally homologous to those of the other hemostatic serine proteases. The mature factor is activated by the cleavage of the activation peptide by factor IXa (in the intrisic pathway), or by factor VIIa (in the extrinsic pathway). The activated factor then converts prothrombin to thrombin in the presence of factor Va, Ca+2, and phospholipid during blood clotting. Mutations of this gene result in factor X deficiency, a hemorrhagic condition of variable severity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Coagulation factor 10; Coagulation factor X; F10; factor Xa; prothrombinase; Stuart factor; Stuart-Prower factor
Gene Aliases: F10; FX; FXA
UniProt ID: (Human) P00742
Entrez Gene ID: (Human) 2159
Molecular Function: annexin calcium-binding protein calmodulin enzyme modulator hydrolase intracellular calcium-sensing protein peptide hormone protease protease inhibitor receptor serine protease signaling molecule
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