|ELISA (ELISA)||Assay Dependent|
|Immunoelectrophoresis (IE)||Assay Dependent|
|Tested Species reactivity||Human|
|Host / Isotype||Goat / IgG|
|Immunogen||Factor XI from human plasma.|
|Storage buffer||0.01M HEPES, pH 7.4, with 0.15M NaCl, 50% glycerol|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
PA1-74033 detects Factor XI from human samples.
PA1-74033 has been successfully used in ELISA and immunoelectrophoresis applications.
The PA1-74033 immunogen is Factor XI from human plasma.
This gene encodes coagulation factor XI of the blood coagulation cascade. This protein is present in plasma as a zymogen, which is a unique plasma coagulation enzyme because it exists as a homodimer consisting of two identical polypeptide chains linked by disulfide bonds. During activation of the plasma factor XI, an internal peptide bond is cleaved by factor XIIa (or XII) in each of the two chains, resulting in activated factor XIa, a serine protease composed of two heavy and two light chains held together by disulfide bonds. This activated plasma factor XI triggers the middle phase of the intrisic pathway of blood coagulation by activating factor IX. Defects in this factor lead to Rosenthal syndrome, a blood coagulation abnormality.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: coagulation factor XI; plasma thromboplastin antecedent; PTA
Gene Aliases: FXI
UniProt ID: (Human) P03951
Entrez Gene ID: (Human) 2160
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