|Western Blot (WB)||1:1000-1:10,000|
|Tested Species reactivity||Human, Mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant fragment corresponding to a region within amino acids 250 and 491 of Human Fibrinogen beta|
|Purification||Antigen affinity chromatography|
|Storage buffer||0.1M tris glycine, pH 7, with 20% glycerol|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
PA5-29805 targets Fibrinogen beta in IF and WB applications and shows reactivity with Human and mouse samples.
The PA5-29805 immunogen is recombinant fragment corresponding to a region within amino acids 250 and 491 of Human Fibrinogen beta.
The protein encoded by this gene is the beta component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including afibrinogenemia, dysfibrinogenemia, hypodysfibrinogenemia and thrombotic tendency.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: B beta polypeptide; epididymis secretory sperm binding protein Li 78p; fibrinogen; Fibrinogen beta chain; fibrinogen, B beta polypeptide
Gene Aliases: 2510049G14Rik; FGB; HEL-S-78p
Molecular Function: signaling molecule
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