|Western Blot (WB)||0.1-0.3 ug/ml|
|Tested Species reactivity||Human|
|Host / Isotype||Goat / IgG|
|Immunogen||Synthetic peptide sequence (RPIKGPREIQLDLE) corresponding to the internal amino acids of FBLN5|
|Purification||Antigen affinity chromatography|
|Storage buffer||TBS, pH 7.3, with 0.5% BSA|
|Contains||0.02% sodium azide|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
This antibody is predicted to react with canine, mouse and rat based on sequence homology.
The protein encoded by this gene is a secreted, extracellular matrix protein containing an Arg-Gly-Asp motif and calcium-binding EGF-like domains. It promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. It is prominently expressed in developing arteries but less so in adult vessels. However, its expression is reinduced in balloon-injured vessels and atherosclerotic lesions, notably in intimal vascular smooth muscle cells and endothelial cells. Therefore, the protein encoded by this gene may play a role in vascular development and remodeling. Defects in this gene are a cause of autosomal dominant cutis laxa, autosomal recessive cutis laxa type I , and age-related macular degeneration type 3 .
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: ARMD3; DANCE; Developmental arteries and neural crest EGF-like protein; developmental arteries and neural crest epidermal growth factor-like; FBLN5; FIBL-5; fibulin 5; Fibulin-5; FLJ90059; testis tissue sperm-binding protein Li 75n; UP50; Urine p50 protein
Gene Aliases: ADCL2; ARCL1A; ARMD3; DANCE; EVEC; FBLN5; FIBL-5; HNARMD; UNQ184/PRO210; UP50
UniProt ID: (Human) Q9UBX5
Entrez Gene ID: (Human) 10516
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