|Western Blot (WB)||1:500-1:3000|
|Tested Species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant fragment corresponding to a region within amino acids 546 and 826 of Human Filamin A alpha 1|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS, pH 7, with 1% BSA, 20% glycerol|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
PA5-29062 targets Filamin A alpha 1 in WB applications and shows reactivity with Human samples.
The PA5-29062 immunogen is recombinant fragment corresponding to a region within amino acids 546 and 826 of Human Filamin A alpha 1.
The protein encoded by this gene is an actin-binding protein that crosslinks actin filaments and links actin filaments to membrane glycoproteins. The encoded protein is involved in remodeling the cytoskeleton to effect changes in cell shape and migration. This protein interacts with integrins, transmembrane receptor complexes, and second messengers. Defects in this gene are a cause of several syndromes, including periventricular nodular heterotopias (PVNH1, PVNH4), otopalatodigital syndromes (OPD1, OPD2), frontometaphyseal dysplasia (FMD), Melnick-Needles syndrome (MNS), and X-linked congenital idiopathic intestinal pseudoobstruction (CIIPX). Two transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: ABP-280; ABPX; actin binding protein 280; Actin-binding protein 280; alpha filamin; Alpha-filamin; CVD1; Endothelial actin-binding protein; filamin A, alpha; Filamin-1; Filamin-A; FLN; FLN-A; FLN1; FMD; MNS; NHBP; Non-muscle filamin; OPD; OPD1; OPD2; XLVD; XMVD
Gene Aliases: ABP-280; ABPX; CSBS; CVD1; FLN; FLN-A; FLN1; FLNA; FMD; MNS; NHBP; OPD; OPD1; OPD2; XLVD; XMVD
UniProt ID: (Human) P21333
Entrez Gene ID: (Human) 2316
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