|Immunofluorescence (IF)||Assay Dependent|
|Western Blot (WB)||Assay Dependent|
|Tested Species reactivity||Bovine, Human, Sheep|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Human and bovine lens filament enriched fraction (plasma membrane cytoskeleton complex).|
|Storage buffer||whole serum|
|Contains||0.1% sodium azide|
|Storage conditions||4° C, do not freeze|
MA1-25031 detects Filensin from human, bovine, and ovine samples. MA1-25031 will not react with mouse, rat, or chicken.
MA1-25031 has been successfully used in Western blot procedures.
The MA1-25031 immunogen is human and bovine lens filament enriched fraction (plasma membrane cytoskeleton complex).
More than 99% of the vertebrate ocular lens is comprised of terminally differentiated lens fiber cells. Two lens-specific intermediate filament-like proteins, CP49 (also known as phakinin) and the protein product of this gene, filensin, are expressed only after fiber cell differentiation has begun. Both proteins are found in a structurally unique cytoskeletal element that is referred to as the beaded filament (BF). Mutations in this gene are the cause of autosomal recessive cortical juvenile-onset cataract. Multiple transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Beaded filament structural protein 1; beaded filament structural protein 1, filensin; CP115; cytoskeletal protein, 115 KD; Filensin; Lens fiber cell beaded-filament structural protein CP 115; Lens intermediate filament-like heavy; LIFL-H; RP4-531H16.2
Gene Aliases: BFSP1; BOS_12927; CP115; CP94; CTRCT33; LIFL-H
UniProt ID: (Human) Q12934
If an Invitrogen™ antibody doesn’t perform as described on our website or datasheet, we’ll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.