|Western Blot (WB)||1:500-1:3000|
|Tested Species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant fragment corresponding to a region within amino acids 222 and 488 of Human Folylpolyglutamate synthase|
|Purification||Antigen affinity chromatography|
|Storage buffer||0.1M tris glycine, pH 7, with 10% glycerol|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
PA5-27914 targets Folylpolyglutamate synthase in WB applications and shows reactivity with Human samples.
The PA5-27914 immunogen is recombinant fragment corresponding to a region within amino acids 222 and 488 of Human Folylpolyglutamate synthase.
This gene encodes the folylpolyglutamate synthetase enzyme. This enzyme has a central role in establishing and maintaining both cytosolic and mitochondrial folylpolyglutamate concentrations and, therefore, is essential for folate homeostasis and the survival of proliferating cells. This enzyme catalyzes the ATP-dependent addition of glutamate moieties to folate and folate derivatives. While several transcript variants may exist for this gene, the full-length natures of only two have been biologically validated to date. These two variants encode distinct isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Folylpoly-gamma-glutamate synthetase; folylpolyglutamate synthase; Folylpolyglutamate synthase, mitochondrial; FPGS; mitochondrial; Tetrahydrofolate synthase; Tetrahydrofolylpolyglutamate synthase
Gene Aliases: FPGS
UniProt ID: (Human) Q05932
Entrez Gene ID: (Human) 2356
Molecular Function: ligase
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