|Immunohistochemistry (Paraffin) (IHC (P))||30 µg/ml|
|Tested Species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic 15 amino acid peptide from N-terminal extracellular domain of human FZD8 / Frizzled 8.|
|Purification||Antigen affinity chromatography|
|Contains||< 0.1% sodium azide|
|Storage conditions||Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C|
Percent identity with other species by BLAST analysis: Human, Monkey, Marmoset, Mouse, Rat, Panda, Opossum (100%).
Members of the Frizzled family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. Frizzled 8 is highly expressed in two human cancer cell lines, indicating that it may play a role in several types of cancer. Its expression has been reported in brain, heart, kidney, pancreas, and skeletal muscle. ESTs have been isolated from embryo, eye, head/neck, heart, kidney, liver/spleen, pancreas, prostate, and testis libraries, as well as many tumor libraries. The crystal structure of the extracellular cysteine-rich domain of a similar mouse protein has been determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Frizzled 8; frizzled 8, seven transmembrane spanning receptor; Frizzled family receptor 8; Frizzled homolog 8; Frizzled-8; FZ-8; Fz8; FZD8; HFZ8
Gene Aliases: FZ-8; FZD8; hFZ8
UniProt ID: (Human) Q9H461
Entrez Gene ID: (Human) 8325
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