|Western Blot (WB)||0.5-2 µg/ml|
|Tested Species reactivity||Bovine, Dog, Chicken, Human, Mouse, Non-human primate, Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide corresponding to residues 150-200 of human LST8.|
|Storage buffer||PBS with 0.2% gelatin|
|Contains||0.05% sodium azide|
|Storage conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
This antibody is 93% homologous to xenopus.
Principal Names: G-protein beta subunit like (GBL protein); MGC111011 Official Gene Symbol: GBL Gen Bank Accession Number: NP_071767 Gene ID: 64223 (Human) Gene Map Locus: 16p13.3 (Human) LST8, a 36-40KDa intracellular protein, is a novel member of WD-40 protein family. It is a highly conserved cytosolic protein consisting of seven WD-40 repeating motifs. LST8 is a functional component of mTOR signaling complex (TORC1) and positively up-regulates the mTOR pathway. It interacts with the kinase domain of mTOR and stabilizes its interaction with raptor. LST8 participates in regulating cell growth and also in nutrient and growth factor-mediated mTOR signaling to S6K1. Reports suggest up-regulated expression of LST8 due to insulin indicating a possible role of LST8 in intracellular events related to insulin-receptor activation including insulin-stimulated glucose transport and glycogen synthesis. Northern Blot analysis detected a ubiquitous expression of LST8 with highest expression in brain and testis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: G beta-like protein; G protein beta subunit-like; Gable; GBL; LST8; Mammalian lethal with SEC13 protein 8; mLST8; MTOR associated protein, LST8 homolog; Protein GbetaL; Target of rapamycin complex subunit LST8; TORC subunit LST8; transducin (beta)-like 4
Gene Aliases: 0610033N12Rik; AA409454; AI505104; AI851821; BOS_22502; GbetaL; GBL; LST8; MLST8; POP3; WAT1
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