|Western Blot (WB)||0.6 ug/ml|
|Tested Species reactivity||Mouse, Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide (coupled with THG) derived from the last 23 aa of mouse GABA B receptor 2. 100% homology with human GB2.|
|Storage buffer||PBS, pH 7.4|
|Contains||15mM sodium azide|
|Storage conditions||4° C, do not freeze|
This antibody recognizes the C-terminus of gamma-aminobutyric acid (GABA) B receptor 2 (epitope: the last 23 aa).
GABA B receptor is a G-protein-coupled inhibitory receptor of gamma-aminobutyric acid (GABA), and has important functions in brain by inhibition of adenylyl cyclase and modulation of G-protein-gated Ca2+ and K+ channels. GABA B receptor is comprised of two subunits, GB1 and GB2 with N-terminal extracellular and C-terminal intracellular domains. The GB1 subunit plays a critical role in ligand binding, whereas the GB2 subunit contains the determinants required for G-protein signaling. Multiple allosteric interactions between the two subunits are required for correct functioning of the receptor. There are two N-terminal splice variants of GB1 subunit, termed GB1a and GB1b; their expression in the central nervous system changes during the ontogenesis and differs between various regions of the brain.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: G protein-coupled receptor 51; G-protein coupled receptor 51; GABA-B R2 receptor; GABA-B receptor 2; GABA-B-R2; GABA-BR2; GABABR2; gamma-aminobutyric acid type B receptor; Gamma-aminobutyric acid type B receptor subunit 2; gamma-aminobutyric acid type B receptor, subunit 2; Gb2; Gm425; Gpr51; ortholog of human G protein-coupled receptor 51 GPR51; RP23-337N2.1; subunit 2
Gene Aliases: GABABR2; Gabbr2; Gb2; Gm425; Gpr51
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