|Western Blot (WB)||Assay Dependent|
|Tested Species reactivity||Human, Mouse, Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide corresponding to residues 377-391 of human GFR -2.|
|Purification||Antigen affinity chromatography|
|Contains||0.02% sodium azide|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
A suggested positive control for this product is HeLa whole cell lysate.
GFRa-2 binds NTN and mediates activation of RET receptor tyrosine kinase by both NTN and GDNF. Thus, NTN, GFRa-2, and the Ret PTK form a complex to transduce NTN signal and to mediate NTN function.
Protein Aliases: GDNF family receptor alpha-2; GDNF receptor alpha-2; GDNF receptor beta; GDNFR-alpha-2; GDNFR-beta; GFR-alpha 2; glial cell line derived neurotrophic factor family receptor alpha 2; glial cell line derived neurotrophic factor receptor, beta; HpV18gp1; Neurturin receptor alpha; NRTNR-alpha; NTNR-alpha; PI-linked cell-surface accessory protein; RET ligand 2; TGF-beta-related neurotrophic factor receptor 2; TRN receptor, GPI-anchored; tyrosine kinase receptor ligand 2
Gene Aliases: GDNFRB; GFRA2; NRTNR-ALPHA; NTNRA; RETL2; TRNR2