|Immunohistochemistry (Paraffin) (IHC (P))||Assay-Dependent|
|Western Blot (WB)||1:500-1:3000|
|Tested Species reactivity||Human, Mouse, Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant fragment corresponding to a region within amino acids 243 and 773 of Human GLI3|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS, pH 7, with 1% BSA, 20% glycerol|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
PA5-28029 targets GLI3 in IF and WB applications and shows reactivity with Human, Rat and mouse samples.
The PA5-28029 immunogen is recombinant fragment corresponding to a region within amino acids 243 and 773 of Human GLI3.
This gene encodes a protein which belongs to the C2H2-type zinc finger proteins subclass of the Gli family. They are characterized as DNA-binding transcription factors and are mediators of Sonic hedgehog (Shh) signaling. The protein encoded by this gene localizes in the cytoplasm and activates patched Drosophila homolog (PTCH) gene expression. It is also thought to play a role during embryogenesis. Mutations in this gene have been associated with several diseases, including Greig cephalopolysyndactyly syndrome, Pallister-Hall syndrome, preaxial polydactyly type IV, and postaxial polydactyly types A1 and B.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: ACLS; anterior digit pattern deformity; brachyphalangy; extra toes; GCPS; GLI-Kruppel family member GLI3; GLI3 form of 190 kDa; GLI3 full length protein; GLI3-190; GLI3FL; glioma-associated oncogene family zinc finger 3; oncogene GLI3; PAP-A; PAPA; PAPA1; PAPB; polydactyly Nagoya; PPDIV; Transcriptional activator GLI3; zinc finger protein GLI3
Gene Aliases: ACLS; add; AI854843; AU023367; Bph; GCPS; GLI3; GLI3-190; GLI3FL; PAP-A; PAPA; PAPA1; PAPB; Pdn; PHS; PPDIV; Xt
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