|Western Blot (WB)||1 µg/ml|
|Tested Species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide corresponding to residues 40-100 of an internal portion of human GLRX. [Swiss-Prot# P35754]|
|Purification||Antigen affinity chromatography|
|Storage buffer||citric acid, pH 7-8|
|Contains||0.1% sodium azide|
|Storage conditions||4° C, do not freeze|
This antibody is predicted to react with mouse, rat, rabbit, porcine, bovine based on 100% sequence homology.
This antibody has 91% sequence homology with zebrafish. It is not recommended for ICC/IF applications.
GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide reductase. It contains a redox active CXXC motif in a TRX fold and uses a similar dithiol mechanism employed by TRXs for intramolecular disulfide bond reduction of protein substrates. Unlike TRX, GRX has preference for mixed GSH disulfide substrates, in which it uses a monothiol mechanism where only the N-terminal cysteine is required. By altering the redox state of target proteins, GRX is involved in many cellular functions including DNA synthesis, signal transduction and the defense against oxidative stress. Different classes are known including human GRX1 (GLRX) and GRX2, which are members of this subfamily. Also included in this subfamily are the N-terminal GRX domains of proteins similar to human thioredoxin reductase 1 and 3.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Glrx; Glrx1; Glutaredoxin; glutaredoxin (thioltransferase); Glutaredoxin-1; Glutaredoxin1; Grx 1; Grx1; MGC117; thioltransferase; Thioltransferase-1; TTase-1
Gene Aliases: GLRX; GRX; GRX1
UniProt ID: (Human) P35754
Entrez Gene ID: (Human) 2745
Molecular Function: oxidoreductase
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