|Western Blot (WB)||1:500-1:1000|
|Tested Species reactivity||Human, Mouse, Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide corresponding to amino acids 831-880 of human GluR- delta2|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS, pH 7.2|
|Contains||0.05% sodium azide|
|Storage conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
This antibody detects endogenous protein at a molecular weight of 113 kDa.
Purity is >95% by SDS-PAGE.
Glutamate receptors mediate most excitatory neurotransmission in the brain and play an important role in neural plasticity, neural development and neurodegeneration. Ionotropic glutamate receptors are categorized into NMDA receptors and kainate/AMPA receptors, both of which contain glutamategated, cation-specific ion channels. Kainate/AMPA receptors co-localize with NMDA receptors in many synapses and consist of seven structurally related subunits, designated GluR-1 to -7, as well as GluR- delta2. The kainate/AMPA receptors are primarily responsible for the fast excitatory neurotransmission by glutamate whereas the NMDA receptors are functionally characterized by a slow kinetic and a high permeability for Ca2+ ions. The NMDA receptors consist of five subunits: epsilon1, 2, 3, 4 and one zeta subunit. The zeta subunit is expressed throughout the brainstem whereas the four epsilon subunits display limited distribution. In mice, mutations in the gene encoding GluR- delta2 (GRID2) cause the Lurcher phenotype. The gene encoding human GluR- delta2 maps to chromosome 4q22.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: creeper; delta-2; GluD2; GluR delta-2 subunit; GluR delta2; GLURD2; glutamate receptor delta-2 subunit; Glutamate receptor ionotropic; Glutamate receptor ionotropic, delta-2; glutamate receptor, ionotropic, delta 2; GRID2; hotfoot; lurcher; minisatellite 10ac detected by probe MMS10
Gene Aliases: B230104L07Rik; cpr; GluD2; GLURD2; GluRdelta2; GRID2; ho; Lc; Lc<J>; MMS10-AC; Ms10ac; nmf408; SCAR18; tpr
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