|Immunohistochemistry (Paraffin) (IHC (P))||3-5 ug/ml|
|Western Blot (WB)||0.1-0.3 ug/ml|
|Tested Species reactivity||Human|
|Host / Isotype||Goat / IgG|
|Immunogen||Synthetic peptide sequence (SGHDNRVSCLGVT) corresponding to the internal amino acids of GNB3|
|Purification||Antigen affinity chromatography|
|Storage buffer||TBS, pH 7.3, with 0.5% BSA|
|Contains||0.02% sodium azide|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
Heterotrimeric guanine nucleotide-binding proteins in this gene is associated with essential hypertension and obesity. This polymorphism is also associated with the occurrence of the splice variant GNB3-s, which appears to have increased activity. GNB3-s is an example of alternative splicing caused by a nucleotide change outside of the splice donor and acceptor sites. Additional splice variants may exist for this gene, but they have not been fully described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: beta polypeptide 3; G protein beta-3 subunit; G protein beta-4 subunit; G protein, beta-3 subunit; GNB3; GNB4; GTP-binding regulatory protein beta-3 chain; guanine nucleotide binding protein; guanine nucleotide binding protein (G protein), beta polypeptide 3; guanine nucleotide binding protein (G protein), beta polypeptide 4; guanine nucleotide-binding protein G(I)/G(S)/G(T) beta subunit 3; Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3; Guanine nucleotide-binding protein subunit beta-4; hypertension associated protein; Transducin beta chain 3; Transducin beta chain 4
Gene Aliases: CMTD1F; CSNB1H; GNB3; GNB4
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