|Immunohistochemistry (Paraffin) (IHC (P))||2 - 4 µg/ml|
|Tested Species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic 18 amino acid peptide from 3rd cytoplasmic domain of human O3FAR1 / GPR120.|
|Purification||Antigen affinity chromatography|
|Contains||< 0.1% sodium azide|
|Storage conditions||Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C|
This antibody is not recommended for use in ICC applications.
Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Bat, Elephant, Rabbit (94%) Marmoset, Mouse, Rat, Pig (89%).
Receptor for medium and long-chain free fatty acids (FFAs). Signals via a G(q)/G(11)-coupled pathway. Acts as a receptor for omega-3 fatty acids and mediates robust anti-inflammatory effects, particularly in macrophages and fat cells. The anti-inflammatory effects involve inhibition of TAK1 through a beta-arrestin 2 (ARRB2)/TAB1-dependent effect, but independent of the G(q)/G(11)-coupled pathway. Mediates potent insulin sensitizing and antidiabetic effects by repressing macrophage-induced tissue inflammation. May mediate the taste of fatty acids. Mediates FFA-induced inhibition of apoptosis in enteroendocrine cells. May play a role in the regulation of adipocyte development and differentiation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: BMIQ10; FFAR4; Free fatty acid receptor 4; G-protein coupled receptor 120; G-protein coupled receptor 129; G-protein coupled receptor GT01; G-protein coupled receptor PGR4; GPR120; GPR129; GT01; O3FAR1; Omega-3 fatty acid receptor 1; PGR4
Gene Aliases: BMIQ10; FFAR4; GPR120; GPR129; GT01; O3FAR1; PGR4
UniProt ID: (Human) Q5NUL3
Entrez Gene ID: (Human) 338557
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