|Immunohistochemistry (Paraffin) (IHC (P))||3 µg/ml|
|Tested Species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic 18 amino acid peptide from 2nd extracellular domain of human GPR183 / EBI2.|
|Purification||Antigen affinity chromatography|
|Contains||< 0.1% sodium azide|
|Storage conditions||Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C|
Percent identity with other species by BLAST analysis: Human, Gorilla, Monkey (100%) Bovine (94%) Hamster, Panda, Bat, Dog, Pig (89%) Marmoset, Horse (83%).
G-protein coupled receptor 183 (EBI2) belongs to the G-protein coupled receptor 1 family of proteins. It is an orphan seven-transmembrane receptor originally identified as most up-regulated gene (>200-fold) in EBV-infected cells. It plays a central role during humoral immunity. It promotes activated B-cell localization in the outer follicle and interfollicular regions. Its specific expression during B-cell maturation helps position B-cells appropriately for mounting T-dependent antibody responses. It is expressed abundantly in lymphoid tissues such as spleen and lymph node, and in B- and T-lymphocytes. It is also reported to be highly expressed in lung, heart and gastrointestinal tract. EBI2 deficiency in mice led to a reduction in the early antibody response to a T-dependent antigen.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: EBI 2; EBI2; EBV-induced G-protein coupled receptor 2; EBV-induced gene 2; Epstein-Barr virus induced gene 2 (lymphocyte-specific G protein-coupled receptor); Epstein-Barr virus-induced G-protein coupled receptor 2; G protein-coupled receptor 183; G-protein coupled receptor 183; GPR183
Gene Aliases: EBI2; GPR183
UniProt ID: (Human) P32249
Entrez Gene ID: (Human) 1880
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