|Immunohistochemistry (Paraffin) (IHC (P))||5 ug/ml|
|Tested Species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Purification||Antigen affinity chromatography|
|Contains||< 0.1% sodium azide|
|Storage conditions||Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C|
Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a stem cell marker of the intestinal epithelium and the hair follicle. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Involved in the development and/or maintenance of the adult intestinal stem cells during postembryonic development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: FEX; G protein-coupled receptor 49; G-protein coupled receptor 49; G-protein coupled receptor 67; G-protein coupled receptor HG38; GPR49; GPR67; GRP49; HG38; leucine-rich repeat containing G protein-coupled receptor 5; leucine-rich repeat-containing G protein-coupled receptor 5; Leucine-rich repeat-containing G-protein coupled receptor 5; LGR5; orphan G protein-coupled receptor HG38
Gene Aliases: FEX; GPR49; GPR67; GRP49; HG38; LGR5
UniProt ID: (Human) O75473
Entrez Gene ID: (Human) 8549
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