|Western Blot (WB)||0.5-1 µg/ml|
|Tested Species reactivity||Human, Yeast|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide (2- Glutathione reductase protein) of GR (2- Glutathione reductase) protein.|
|Storage buffer||PBS with 0.05% BSA|
|Contains||0.05% sodium azide|
|Storage conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
Glutathione reductase (GSR or GR) is a crucial flavoenzyme in the antioxidant defense system that maintains high levels of reduced glutathione in the cytosol. It belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family and is a flavoprotein homodimer of two equal subunits with one mole of noncovalently bound FAD in each subunit. GR reduces glutathione disulphide (GSSG) to the sulfhydryl form (GSH) which is an important cellular oxidant and is used by glutathione peroxidase to detoxify hydrogen peroxide. Apart from NADPH, GR also uses FAD as a cofactor for the process. In sperm, GR and glutathione peroxidase function as antioxidant enzymes and thus may inhibit lipid peroxidation. GR is stimulated by melatonin and is reportedly irreversibly inhibited by a number of oxygen radical generating systems.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: epididymis luminal protein 75; epididymis secretory sperm binding protein Li 122m; glutathione reductase; Glutathione reductase, mitochondrial; glutathione S-reductase; GR; GRase; mitochondrial
Gene Aliases: GLUR; GRD1; GSR; HEL-75; HEL-S-122m
UniProt ID: (Human) P00390
Entrez Gene ID: (Human) 2936
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