|Western Blot (WB)||1:500-1:3000|
|Tested Species reactivity||Human, Mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide corresponding to a region within amino acids 752 and 814 of Human GRAF|
|Purification||Antigen affinity chromatography|
|Storage buffer||0.1M tris glycine, pH 7, with 10% glycerol|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
PA5-28703 targets GRAF in WB applications and shows reactivity with Human and mouse samples.
The PA5-28703 immunogen is synthetic peptide corresponding to a region within amino acids 752 and 814 of Human GRAF.
Interaction of a cell with the extracellular matrix triggers integrin cell surface receptors to begin signaling cascades that regulate the organization of the actin-cytoskeleton. One of the proteins involved in these cascades is focal adhesion kinase. The protein encoded by this gene is a GTPase activating protein that binds to focal adhesion kinase and mediates the activity of the GTP binding proteins RhoA and Cdc42. Defects in this gene are a cause of juvenile myelomonocytic leukemia (JMML). Two transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: GRAF; GRAF1; GTPase regulator associated with focal adhesion kinase; GTPase regulator associated with focal adhesion kinase pp125(FAK); Oligophrenin-1-like protein; OPHN1L; OPHN1L1; Rho GTPase-activating protein 26; Rho-type GTPase-activating protein 26
Gene Aliases: 1810044B20Rik; 2610010G17Rik; 4933432P15Rik; AI853435; ARHGAP26; GRAF; GRAF1; KIAA0621; mKIAA0621; OPHN1L; OPHN1L1
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