|Immunohistochemistry (Paraffin) (IHC (P))||1:100-1:1000|
|Western Blot (WB)||1:500-1:3000|
|Tested Species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant protein fragment corresponding to a region within amino acids 1 and 594 of Human GRB10|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS, pH 7, with 20% glycerol|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
PA5-32239 targets GRB10 in WB applications and shows reactivity with Human samples.
The PA5-32239 immunogen is recombinant protein fragment corresponding to a region within amino acids 1 and 594 of Human GRB10.
The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. Overexpression of some isoforms of the encoded protein inhibits tyrosine kinase activity and results in growth suppression. This gene is imprinted in a highly isoform- and tissue-specific manner. Alternatively spliced transcript variants encoding different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Grb-10; GRB-IR; GRB10 adapter protein; GRB10 adaptor protein; Growth factor receptor-bound protein 10; Insulin receptor-binding protein Grb-IR; maternally expressed gene 1; MEG1; RSS
Gene Aliases: Grb-10; GRB-IR; GRB10; GRBIR; IRBP; KIAA0207; MEG1; RSS
UniProt ID: (Human) Q13322
Entrez Gene ID: (Human) 2887
Molecular Function: transmembrane receptor regulatory/adaptor protein
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