|Western Blot (WB)||1:500-1:3000|
|Tested Species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant protein fragment corresponding to a region within amino acids 13 and 161 of Human GRP1|
|Purification||Antigen affinity chromatography|
|Storage buffer||0.1M tris glycine, pH 7, with 20% glycerol|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
PA5-30307 targets GRP1 in IF and WB applications and shows reactivity with Human samples.
The PA5-30307 immunogen is recombinant protein fragment corresponding to a region within amino acids 13 and 161 of Human GRP1.
This gene encodes a member of the PSCD (pleckstrin homology, Sec7 and coiled-coil domains) family. PSCD family members have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. This encoded protein is involved in the control of Golgi structure and function, and it may have a physiological role in regulating ADP-ribosylation factor protein 6 (ARF) functions, in addition to acting on ARF1.
Protein Aliases: ARF nucleotide-binding site opener 3; ARNO3; Cytohesin-3; General receptor of phosphoinositides 1; GRP1; PH; PH, SEC7 and coiled-coil domain-containing protein 3; pleckstrin homology; pleckstrin homology, Sec7 and coiled-coil domains 3; Protein ARNO3; PSCD3; SEC7 and coiled-coil domain-containing protein 3; Sec7 and coiled-coil domains 3
Gene Aliases: ARNO3; CYTH3; GRP1; PSCD3
UniProt ID: (Human) O43739
Entrez Gene ID: (Human) 9265