|Immunohistochemistry (Paraffin) (IHC (P))||1:100|
|Tested Species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide from C-terminus of human GluR6/7.|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS, pH 7.6, with 1% BSA|
|Contains||<0.1% sodium azide|
|Storage conditions||4° C, do not freeze|
Heat-mediated antigen retrieval is recommended prior to staining, using a 10mM citrate buffer, pH 6.0, for 10 minutes followed by cooling at room temperature for 20 min. Following antigen retrieval, incubate samples with primary antibody for 30 min at room temperature. A suggested positive control is brain tissue.
Glutamate receptors constitute the principal excitatory neurotransmitter receptors in brain. Two classes of glutamate receptors exist: ionotropic receptors, and metabotropic receptors. Ionotropic glutamate receptors are oligomeric complexes of various subunits (GluR1-7, NMDA1-3, KAI-2), which comprise ligand-gated calcium channels. Metabotropic glutamate receptors are G-protein coupled receptors, which when activated can activate phopholipases or adenylylcyclase, depending on the neuron.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: bA487F5.1; dJ1090M5.1 (glutamate receptor, ionotropic, kainate 3 (GLUR7)); EAA4; EAA5; Excitatory amino acid receptor 4; Excitatory amino acid receptor 5; GLR6; GluK2; GluK3; GLUK6; GluR-6; GluR-7; GLUR6; Glutamate Receptor 6; Glutamate Receptor 6/7; Glutamate Receptor 7; glutamate receptor form A; glutamate receptor form B; glutamate receptor form C; glutamate receptor form D; glutamate receptor form E; Glutamate receptor ionotropic, kainate 2; Glutamate receptor ionotropic, kainate 3; glutamate receptor, ionotropic, kainate 2; glutamate receptor, ionotropic, kainate 3; GRIK2; GRIK3; MRT6
Gene Aliases: EAA4; EAA5; GLR6; GLR7; GluK2; GluK3; GLUK6; GLUR6; GLUR7; GluR7a; GRIK2; GRIK3; MRT6
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