|Immunofluorescence (IF)||1/10 - 1/100|
|Immunohistochemistry (Frozen) (IHC (F))||Assay Dependent|
|Immunohistochemistry (Paraffin) (IHC (P))||1/500 - 1/4000|
|Western Blot (WB)||1/50 - 1/500|
|Western Blot (WB)||See 1 publications below|
|Tested Species reactivity||Dog, Cat, Human, Sheep, Rat|
|Published species reactivity||Not Applicable|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Growth hormone from ovine pituitary.|
|Contains||0.09% sodium azide|
|Storage conditions||4°C or -20°C if preferred|
In Western blot applications a band at ~20 kDa is seen in human pituitary gland lysates.
The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones which play an important role in growth control. The gene, along with four other related genes, is located at the growth hormone locus on chromosome 17 where they are interspersed in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. The five genes share a remarkably high degree of sequence identity. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. This particular family member is expressed in the pituitary but not in placental tissue as is the case for the other four genes in the growth hormone locus. Mutations in or deletions of the gene lead to growth hormone deficiency and short stature.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: GH; Growth hormone; Growth hormone 1; growth hormone 12; growth hormone B5; Pituitary growth hormone; Somatotropin
Gene Aliases: GH; GH-N; GH1; GHB5; GHN; hGH-N; IGHD1B; RNGHGP
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