|Immunohistochemistry (Paraffin) (IHC (P))||1:100|
|Tested Species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide derived from internal region of human guanylyl cyclase beta 1, soluble.|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS, pH 7.6, with 1% BSA|
|Contains||<0.1% sodium azide|
|Storage conditions||4° C, do not freeze|
Heat-mediated antigen retrieval is recommended prior to staining, using a 10mM citrate buffer, pH 6.0, for 10 minutes followed by cooling at room temperature for 20 min. Following antigen retrieval, incubate samples with primary antibody for 10 min at room temperature. A suggested positive control is brain tissue.
Soluble guanylyl cyclase catalyses in a Mg2+ or Mn2+ dependent manner, the conversion of guanosine-5 and quote;-triphosphate (GTP) to cyclic guanosine-3 and quote;,5-monophosphate (cGMP) and pyrophosphate. This enzyme is a major physiological receptor for nitric oxide (NO), an important intra- and intercellular membrane-permeant signaling molecule.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: GC-S-beta-1; GC-SB3; GCS-beta-1; GCS-beta-3; guanylate cyclase 1, soluble, beta 3; Guanylate cyclase soluble subunit beta-1; Guanylate cyclase soluble subunit beta-3; GUC1B3; GUCB3; GUCSB3; GUCY1B1; Soluble guanylate cyclase small subunit
Gene Aliases: GC-S-beta-1; GC-SB3; GUC1B3; GUCB3; GUCSB3; GUCY1B1; GUCY1B3
UniProt ID: (Human) Q02153
Entrez Gene ID: (Human) 2983
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