|Western Blot (WB)||Assay Dependent|
|Tested Species reactivity||Mouse, Rat|
|Host / Isotype||Chicken / IgY|
|Immunogen||Synthetic peptide corresponding to human GTPase HRas.|
|Purification||Antigen affinity chromatography|
|Storage conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
PA1-27524 detects HRAS from mouse and rat samples.
PA1-27524 may be successfully used in Western blot applications.
The PA1-27595 immunogen is a synthetic peptide corresponding to human GTPase HRas.
This gene belongs to the Ras oncogene family, whose members are related to the transforming genes of mammalian sarcoma retroviruses. The products encoded by these genes function in signal transduction pathways. These proteins can bind GTP and GDP, and they have intrinsic GTPase activity. This protein undergoes a continuous cycle of de- and re-palmitoylation, which regulates its rapid exchange between the plasma membrane and the Golgi apparatus. Mutations in this gene cause Costello syndrome, a disease characterized by increased growth at the prenatal stage, growth deficiency at the postnatal stage, predisposition to tumor formation, mental retardation, skin and musculoskeletal abnormalities, distinctive facial appearance and cardiovascular abnormalities. Defects in this gene are implicated in a variety of cancers, including bladder cancer, follicular thyroid cancer, and oral squamous cell carcinoma. Multiple transcript variants, which encode different isoforms, have been identified for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: c-H-ras; c-Ha-ras p21 protein; c-Ha-ras transgene; GTPase HRas; H-ras 1 protein; H-Ras-1; Harvey ras1 protein; Harvey rat sarcoma viral (v-Ha-ras) oncogene homolog; Harvey rat sarcoma virus oncogene 1; Harvey-ras; Hras; Hras1; p21ras; Ras; Transforming protein p21
Gene Aliases: c-H-ras; c-Ha-ras; c-rasHa; H-ras; Ha-ras; Harvey-ras; Hras; Hras-1; HRAS1; Kras2; ras
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