|Immunohistochemistry (Paraffin) (IHC (P))||5-10 µg/ml|
|Western Blot (WB)||0.5-2 µg/ml|
|Tested Species reactivity||Dog, Human, Mouse, Non-human primate, Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide (875 DTDEEETSQRHSLR 888) of HIPK3 protein.|
|Purification||Antigen affinity chromatography|
|Contains||0.05% sodium azide|
|Storage conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
HIPK3, a mammalian homolog of YAK1, is a novel 130 kDa nuclear co-factor that belongs to the HIPK protein family. Members of this family localize to nuclear speckles and consist of an evolutionarily conserved protein kinase domain and a homeoprotein-interacting domain. Physiological functions of HIPK3 have been predicted in different cell signaling pathways including transcriptional co-repression, cell differentiation, growth suppression, steroidogenesis and apoptosis. Research suggests that HIPK3 is a FADD-interacting protein kinase found to phosphorylate FADD and promote its binding to Fas, thereby inhibiting Fas-mediated Jun NH (2)-terminal kinase activation. HIPK3 also has been found to phosphorylate JNK and c-JUN, thus enhancing SF-1 activity for CYP11A1 transcription. HIPK3 plays a key role in cAMP-dependant signaling pathway.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Androgen receptor-interacting nuclear protein kinase; ANPK; DYRK6; Fas-interacting serine/threonine-protein kinase; FIST; FIST3; HCMV-interacting protein; Homeodomain-interacting protein kinase 3; Homolog of protein kinase YAK1; Nbak3; Nuclear body-associated kinase 3; nuclear serine/threonine protein kinase; PKY; RP1-8L15.1; YAK1
Gene Aliases: ANPK; DYRK6; Fist; FIST3; HIPK3; mir-1902; PKY; YAK1
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