|Western Blot (WB)||1:500-1:3000|
|Tested Species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant protein fragment corresponding to a region within amino acids 1 and 246 of Human HLA-DPB1|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS, pH 7, with 1% BSA, 20% glycerol|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
PA5-27780 targets HLA-DPB1 in WB applications and shows reactivity with Human samples.
The PA5-27780 immunogen is recombinant protein fragment corresponding to a region within amino acids 1 and 246 of Human HLA-DPB1.
HLA-DPB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta chain (DPB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: beta-1 subunit; beta1 domain MHC class II HLA DPB; class II HLA beta chain; DP beta 1 chain; DP(W4) beta chain; DPB1; HLA class II histocompatibility antigen; HLA class II histocompatibility antigen, DP beta 1 chain; HLA class II histocompatibility antigen, DP(W4) beta chain; HLA DP14-beta chain; HLA-DP; HLA-DP histocompatibility type; HLA-DP histocompatibility type, beta-1 subunit; HLA-DP1B; HLA-DPB; major histocompatibility complex class II antigen beta chain; MHC cla; MHC class II antigen beta chain; MHC class II antigen DP beta 1 chain; MHC class II antigen DPB1; MHC class II antigen DPbeta1; MHC class II HLA-DP-beta; MHC class II HLA-DP-beta-1; MHC class II HLA-DRB1; MHC HLA DPB1
Gene Aliases: DPB1; HLA-DP; HLA-DP1B; HLA-DPB; HLA-DPB1
UniProt ID: (Human) Q30174
Entrez Gene ID: (Human) 3115
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