|Immunohistochemistry (Paraffin) (IHC (P))||1:100-1:1000|
|Western Blot (WB)||1:5000-1:20,000|
|Tested Species reactivity||Human, Mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant protein fragment corresponding to a region within amino acids 1 and 133 of Human HP1 gamma|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS, pH 7, with 1% BSA, 20% glycerol|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
PA5-30954 targets HP1 gamma in IF, IHC (P), and WB applications and shows reactivity with Human samples.
The PA5-30954 immunogen is recombinant protein fragment corresponding to a region within amino acids 1 and 133 of Human HP1 gamma.
At the nuclear envelope, the nuclear lamina and heterochromatin are adjacent to the inner nuclear membrane. The protein encoded by this gene binds DNA and is a component of heterochromatin. This protein also can bind lamin B receptor, an integral membrane protein found in the inner nuclear membrane. The dual binding functions of the encoded protein may explain the association of heterochromatin with the inner nuclear membrane. Two transcript variants encoding the same protein but differing in the 5' UTR, have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: chromobox homolog 3; chromobox homolog 3 (HP1 gamma homolog; chromobox homolog 3 (HP1 gamma homolog, Drosophila); Chromobox protein homolog 3; Drosophila); HECH; heterochromatin protein 1 gamma; Heterochromatin protein 1 homolog gamma; heterochromatin protein HP1 gamma; heterochromatin-like protein 1; HP1 gamma; HP1 gamma homolog; HP1-GAMMA; HP1Hs-gamma; Modifier 2 protein
Gene Aliases: CBX3; HECH; HP1-GAMMA; HP1g; HP1Hs-gamma; M32
UniProt ID: (Human) Q13185
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