|Western Blot (WB)||2 - 5 ug/ml|
|Tested Species reactivity||Human, Mouse, Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||15 amino acid peptide from near the centre of human HRK|
|Contains||0.02% sodium azide|
|Storage conditions||4°C or -20°C if preferred|
In Western blot, this antibody detects a band at ~13 kDa in mouse pancreas tissue lysate.
Activator of apoptosis Hrk regulates apoptosis through interaction with death-repressor proteins Bcl-2 and Bcl-X(L). The HRK protein lacks significant homology to other BCL2 family members except for an 8-amino acid region that was similar to the BCL2 homology domain-3 (BH3) motif of BIK. HRK interacts with BCL2 and BCLXL via the BH3 domain, but not with the death-promoting BCL2-related proteins BAX, BAK, or BCLXS. HRK localizes to membranes of intracellular organelles in a pattern similar to that previously reported for BCL2 and BCLXL.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Activator of apoptosis harakiri; activator of apoptosis Hrk; BCL2-interacting protein; BH3 interacting (with BCL2 family) domain, apoptosis agonist; BH3-interacting domain-containing protein 3; death protein 5; DP5; HARAKIRI; harakiri, BCL2 interacting protein (contains only BH3 domain); Neuronal death protein DP5
Gene Aliases: AI838259; BID3; DP5; HARAKIRI; HRK
If an Invitrogen™ antibody doesn’t perform as described on our website or datasheet, we’ll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.