|Immunohistochemistry (Paraffin) (IHC (P))||1:100-1:1000|
|Western Blot (WB)||1:500-1:3000|
|Tested Species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant fragment contain a sequence corresponding to a region within amino acids 98 and 458 of HTRA2|
|Purification||Antigen affinity chromatography|
|Storage buffer||0.1M tris glycine, pH 7, with 10% glycerol|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
PA5-29182 targets HTRA2 in IHC (P) and WB applications and shows reactivity with Human samples.
The PA5-29182 immunogen is a recombinant fragment corresponding to a region within amino acids 98 and 458 of HTRA2.
This gene encodes a serine protease. The protein has been localized in the endoplasmic reticulum and interacts with an alternatively spliced form of mitogen-activated protein kinase 14. The protein has also been localized to the mitochondria with release to the cytosol following apoptotic stimulus. The protein is thought to induce apoptosis by binding the apoptosis inhibitory protein baculoviral IAP repeat-containing 4. Nuclear localization of this protein has also been observed. Alternate splicing of this gene results in two transcript variants encoding different isoforms. Additional transcript variants have been described, but their full-length sequences have not been determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 25; High temperature requirement protein A2; HtrA-like serine protease; HtrA2; mitochondrial; OMI; Omi stress-regulated endoprotease; PARK13; protease; protease, serine, 25; PRSS25; serine; Serine protease 25; serine protease HTRA2; Serine protease HTRA2, mitochondrial; Serine proteinase OMI
Gene Aliases: HTRA2; OMI; PARK13; PRSS25
UniProt ID: (Human) O43464
Entrez Gene ID: (Human) 27429
If an Invitrogen™ antibody doesn’t perform as described on our website or datasheet, we’ll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.