|ELISA (ELISA)||Assay Dependent|
|Western Blot (WB)||Assay Dependent|
|Tested Species reactivity||Human, Mouse, Rat|
|Host / Isotype||Chicken / IgY|
|Immunogen||Human plasma protein.|
|Purification||Antigen affinity chromatography|
|Contains||0.01% sodium azide|
|Storage conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
PA1-25689 detects Haptoglobin from human, mouse, and rat samples.
PA1-25689 has been successfully used in Western blot and ELISA procedures. The predicted molecular weight is 45 kDa.
The PA1-25689 immunogen is human plasma protein.
Store at 4°C short term. For extended storage aliquot and store at -20°C or below, avoiding freeze/thaw cycles.
This gene encodes a preproprotein, which is processed to yield both alpha and beta chains, which subsequently combine as a tetramer to produce haptoglobin. Haptoglobin functions to bind free plasma hemoglobin, which allows degradative enzymes to gain access to the hemoglobin, while at the same time preventing loss of iron through the kidneys and protecting the kidneys from damage by hemoglobin. Mutations in this gene and/or its regulatory regions cause ahaptoglobinemia or hypohaptoglobinemia. This gene has also been linked to diabetic nephropathy, the incidence of coronary artery disease in type 1 diabetes, CrohNULLs disease, inflammatory disease behavior, primary sclerosing cholangitis, susceptibility to idiopathic ParkinsoNULLs disease, and a reduced incidence of Plasmodium falciparum malaria. A similar duplicated gene is located next to this gene on chromosome 16. Multiple transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: binding peptide; BP; Haptoglobin; haptoglobin alpha(1S)-beta; haptoglobin alpha(2FS)-beta; haptoglobin, alpha polypeptide; haptoglobin, beta polypeptide; HP2-ALPHA-2; HPA1S; Liver regeneration-related protein LRRG173; MGC111141; Zonulin
Gene Aliases: Ba1-647; BP; HP; HP-1; HP2ALPHA2; HPA1S; preHP2
Molecular Function: annexin calcium-binding protein calmodulin enzyme modulator hydrolase intracellular calcium-sensing protein peptide hormone protease protease inhibitor receptor serine protease signaling molecule
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