|Western Blot (WB)||Assay Dependent|
|Immunohistochemistry (IHC)||See 5 publications below|
|Blocking Assay (BLOCK)||See 1 publications below|
|Tested Species reactivity||Bovine, Human|
|Published species reactivity||Pig , Sheep , Bovine Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant human IL-1 alpha|
|Purification||Ammonium sulfate precipitation|
P420A targets IL-1 alpha in WB applications and shows reactivity with Bovine, and Human samples.
The P420A immunogen is recombinant human IL-1 alpha.
P420A detects IL-1 alpha which has a predicted molecular weight of approximately 18 kDa.
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. This cytokine is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury, and thus induces apoptosis. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. It has been suggested that the polymorphism of these genes is associated with rheumatoid arthritis and Alzheimer's disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Hematopoietin-1; IL-1 alpha; interleukin 1, alpha; Interleukin-1 alpha; preinterleukin 1 alpha; pro-interleukin-1-alpha
Gene Aliases: BOS_11618; IL-1A; IL1; IL1-ALPHA; IL1A; IL1F1
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