|ELISA (ELISA)||Assay Dependent|
|Immunohistochemistry (IHC)||Assay Dependent|
|Neutralization (Neu)||Assay Dependent|
|Western Blot (WB)||Assay Dependent|
|Immunohistochemistry (IHC)||See 5 publications below|
|Blocking Assay (BLOCK)||See 3 publications below|
|Western Blot (WB)||See 1 publications below|
|ELISA (ELISA)||See 1 publications below|
|Immunocytochemistry (ICC)||See 1 publications below|
|Tested Species reactivity||Human, Mouse, Non-human primate|
|Published species reactivity||Human Mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant human IL-1 beta|
|Purification||Ammonium sulfate precipitation|
P420B targets IL-1 beta in ELISA, IHC, Neu, and WB applications and shows reactivity with Human, mouse, and Non-human primate samples.
The P420B immunogen is recombinant human IL-1 beta.
P420B detects IL-1 beta which has a predicted molecular weight of approximately 31 kDa.
This product is a Low Endotoxin formulation.
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Catabolin; IL-1 beta; IL-1beta; interleukin 1, beta; Interleukin-1 beta; preinterleukin 1 beta; pro-interleukin-1-beta
Gene Aliases: IL-1; Il-1b; IL-1beta; IL1-BETA; IL1B; IL1F2
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