|Immunohistochemistry (IHC)||5 µg/ml|
|Western Blot (WB)||0.5-2 ug/ml|
|Tested Species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||A synthetic peptide corresponding to amino acids at the C-terminus of human ILPIP.|
|Purification||Antigen affinity chromatography|
|Contains||0.02% sodium azide|
|Storage conditions||Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
In Western blot applications, this antibody detects a band at ~34kDa. A suggested positive control is human heart tissue lysate.
PA5-20036 can be used with blocking peptide PEP-0155.
ILPIP (ILP-interacting protein) has recently been shown to interact with XIAP, a member of the IAP (Inhibitor of Apoptosis) protein family. Together, these two proteins synergistically activate the TAK1/JNK1 signal transduction pathway, which acts to protect against the interleukin-1-b converting enzyme of Fas-induced apotosis. This protein was independently isolated and characterized as polyploidy-associated protein kinase (PAPK), a member of the Ste20/germinal center kinase family that modulates cytoskeletal organization and cell survival, suggesting that its protective role may be a function of its kinase activity. Although two mRNA sequences have been isolated, only the shorter isoform has been observed.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 2; Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein; CALS-21; ILP-interacting protein; ILP-interacting protein ILPIPA; PRO1038, ALS2CR2, CALS-21, ILPIP, ILPIPA, PAPK; Pseudokinase ALS2CR2; STE20-related kinase adapter protein beta; STRAD beta
Gene Aliases: ALS2CR2; CALS-21; ILPIP; ILPIPA; PAPK; PRO1038; STRADB
UniProt ID: (Human) Q9C0K7
Entrez Gene ID: (Human) 55437
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