|Immunohistochemistry (Paraffin) (IHC (P))||1:100-1:1000|
|Western Blot (WB)||1:500-1:3000|
|Tested Species reactivity||Human, Mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant fragment corresponding to a region within amino acids 276 and 506 of Human IMPDH2|
|Storage buffer||PBS, pH 7, with 40% glycerol|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
PA5-27519 targets IMPDH2 in IF and WB applications and shows reactivity with Human and mouse samples.
The PA5-27519 immunogen is recombinant fragment corresponding to a region within amino acids 276 and 506 of Human IMPDH2.
This gene encodes the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. The encoded protein catalyzes the NAD-dependent oxidation of inosine-5'-monophosphate into xanthine-5'-monophosphate, which is then converted into guanosine-5'-monophosphate. This gene is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: IMP (inosine 5'-monophosphate) dehydrogenase 2; IMP (inosine monophosphate) dehydrogenase 2; IMP dehydrogenase 2; IMP dehydrogenase type II; IMP oxireductase 2; IMPD 2; IMPD2; IMPDH 2; IMPDH-II; IMPDH2; inosine 5' phosphate dehydrogenase 2; inosine monophosphate dehydrogenase type II; Inosine-5'-monophosphate dehydrogenase 2
Gene Aliases: IMPD; IMPD2; IMPDH-II; IMPDH2
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