|Western Blot (WB)||1:2,000|
|Tested Species reactivity||Human, Mouse, Rat|
|Host / Isotype||Chicken / IgY|
|Immunogen||Synthetic peptide corresponding to residues 1-60 of ITM2B.|
|Purification||Antigen affinity chromatography|
|Storage conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
PA1-25724 detects ITM2B from human, mouse, and rat samples.
PA1-25724 has been successfully used in Western blot procedures.
The PA1-25724 immunogen is a synthetic peptide corresponding to residues 1-60 of ITM2B.
Amyloid precursor proteins are processed by beta-secretase and gamma-secretase to produce beta-amyloid peptides which form the characteristic plaques of Alzheimer disease. This gene encodes a transmembrane protein which is processed at the C-terminus by furin or furin-like proteases to produce a small secreted peptide which inhibits the deposition of beta-amyloid. Mutations which result in extension of the C-terminal end of the encoded protein, thereby increasing the size of the secreted peptide, are associated with two neurogenerative diseases, familial British dementia and familial Danish dementia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: ABRI; ABri/ADan amyloid peptide; BRI; BRI2; BRICD2B; BRICHOS domain containing 2B; E25B; E3-16; FBD; imBRI2; Immature BRI2; Integral membrane protein 2B; Integral membrane protein 2B (E25B protein); Protein E25B; RP11-196P14.1; Transmembrane protein BRI
Gene Aliases: ABRI; AI256040; BRI; BRI2; BRICD2B; D14Sel6; E25B; E25BMM; E3-16; FBD; imBRI2; ITM2B; RDGCA
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